The results of analysis of the operating mode of power system of the Republic Moldova when accomplishing the interconnection with the power system of Romania using the Back-to-Back (BtB) power unit at the transformer station Vulcanesti have been presented in the paper. Installation of BtB leads to the loading of overhead power line (OPL) 330kV Vulcanesti-Chisinau up to 571 MW with the change of the value and the direction of power flux in OPL from Chisinau toward Kuchurgan power station, the decrease of power flux entering the north of the country (OPL 330kV HPP Dnestrovsk - Balti) and in the OPL 330kV (Kotovsk- Kuchurgan power station).
It is pointed that the accomplishment of asynchronous interconnection with Romania has the impact at regional scale causing the change of power fluxes both in the power system of the Republic of Moldova and of Ukraine with Romania including the Moldovan GRES.
The task is put on the need for a comprehensive study of the new operating conditions of the Moldovan energy system. It is also necessary to take into account the interests of the energy systems of Ukraine and Romania, as well as the Moldovan GRES when considering further directions for the development of the region's energy, including technical and economic aspects.